Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geometrically Constrained Growth Factor Concentration Favors Enrichment of Goblet Cells and Mucus Formation.

ACS biomaterials science & engineering·2026
Same author

Development of large-scale gastruloid array to identify aberrant developmental phenotypes.

APL bioengineering·2025
Same author

Imaging 3D cell cultures with optical microscopy.

Nature methods·2025
Same author

Thin Layer Chromatography Goes Ultrasmall to Assay Sphingosine Kinase Activation in Single Primary Leukemic Cells.

Analytical chemistry·2025
Same author

Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model.

Frontiers in bioengineering and biotechnology·2024
Same author

A Microphysiological System with an Anaerobic Air-Liquid Interface and Functional Mucus Layer for Coculture of Intestinal Bacteria and Primary Human Colonic Epithelium.

Advanced materials interfaces·2024
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Dissolution-guided wetting for microarray and microfluidic devices.

Yuli Wang1, Christopher E Sims, Nancy L Allbritton

  • 1Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.

Lab on a Chip
|July 21, 2012
PubMed
Summary
This summary is machine-generated.

Coating microfluidic devices with monosaccharides like D-glucose passively eliminates air bubbles. This simple method ensures microcavities remain functional after prolonged air exposure, improving lab-on-a-chip usability.

More Related Videos

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay
08:22

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay

Published on: February 23, 2020

Related Experiment Videos

Last Updated: May 20, 2026

Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay
08:22

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay

Published on: February 23, 2020

Area of Science:

  • Biotechnology
  • Materials Science
  • Microfluidics

Background:

  • Air bubble entrapment hinders the performance of microfluidic devices with microcavities.
  • Lab-on-a-chip technology is expanding, making bubble elimination crucial for reliable operation.

Purpose of the Study:

  • To develop a simple, passive method for eliminating air bubbles in microfluidic devices.
  • To enhance the usability and reliability of lab-on-a-chip systems.

Main Methods:

  • Hydrophilized microarray and microfluidic devices were coated with monosaccharides (D-glucose, D-sorbitol).
  • Monosaccharide coating formed conformal, solid structures within microcavities.
  • Devices were stored in air for up to 6 months.

Main Results:

  • The monosaccharide coating effectively prevented air bubble trapping.
  • Dissolving the monosaccharide with an aqueous solution achieved complete rewetting of microcavities.
  • The method demonstrated efficacy for microcavities including microwells, traps, dead ends, and corners.

Conclusions:

  • Monosaccharide coating offers a simple, passive, and effective solution for air bubble elimination in microfluidic devices.
  • This technique ensures the long-term functionality and rewetting of microcavities, enhancing lab-on-a-chip performance.