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Related Experiment Video

Updated: Jan 1, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
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Perimenstrual headache in adolescence.

Andrew D Hershey1

  • 1Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH 45229-3039, USA. Andrew.Hershey@cchmc.org

Current Pain and Headache Reports
|July 21, 2012
PubMed
Summary

Childhood headaches are often migraines, increasing during puberty. Hormonal changes, particularly in girls, contribute to menstrual-related migraine development.

Area of Science:

  • Neurology
  • Pediatrics
  • Endocrinology

Background:

  • Recurrent headaches are a frequent childhood complaint, with migraines being the most common diagnosis.
  • Headache incidence and prevalence rise during adolescence, coinciding with puberty.
  • A notable shift in the male-to-female ratio of migraine sufferers occurs during this period.

Purpose of the Study:

  • To review recent advances in understanding the development of menstrual-related migraine.
  • To explore the link between hormonal progression during puberty and migraine presentation in adolescents.

Main Methods:

  • Literature review of studies on adolescent headaches and migraines.
  • Analysis of epidemiological data on headache prevalence by age and sex.
  • Examination of research on hormonal influences on migraine pathophysiology.

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Main Results:

  • Migraine prevalence increases significantly in adolescents.
  • The ratio of migraine in girls to boys becomes more pronounced during puberty.
  • Hormonal changes associated with puberty and menstruation are implicated as key factors.

Conclusions:

  • Pubertal hormonal progression is a significant factor in the increased incidence and altered sex ratio of migraines in adolescents.
  • Menstrual-related migraine is a distinct entity whose development is increasingly understood.
  • Further research into hormonal mechanisms is crucial for targeted adolescent migraine therapies.