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Diabetes and chronic oxidative stress. A perspective based on the possible usefulness of ozone therapy

Velio Bocci1, Iacopo Zanardi, Maya S P Huijberts

  • 1Department of Physiology, University of Siena, Via A. Moro 2, 53100 Siena, Italy. bocci@unisi.it

Diabetes & Metabolic Syndrome
|July 21, 2012
PubMed

Insights

Oxygen-ozonetherapy shows promise for improving diabetes prognosis by correcting hyperglycemia-induced vascular damage. This novel approach involves treating patient blood ex vivo with ozone to restore cellular functions and break the disease cycle.

Area of Science:

  • Biomedical science
  • Vascular biology
  • Endocrinology

Background:

  • Hyperglycemia in diabetes (type 1 and 2) causes biochemical derangements.
  • This leads to widespread vascular damage and various pathological conditions.
  • Current treatment limitations exist due to unreliable administration routes in preclinical and clinical studies.

Purpose of the Study:

  • To explore the potential of oxygen-ozonetherapy as a novel treatment for diabetes.
  • To investigate if this therapy can mitigate hyperglycemia-induced vascular damage.
  • To open a discussion on improving diabetes prognosis with this therapeutic approach.

Main Methods:

  • A precise ex vivo interaction of patient blood with a calculated dose of ozone (0.42-0.84 mM).
  • Infusion of treated blood back into the patient.
  • Observation of cellular responses and functional restoration.

Main Results:

  • Ozone therapy generates messengers that interact with various cells.
  • These messengers help restore cellular functions disrupted by hyperglycemia.
  • Potential to break the vicious cycle of diabetes-related complications.

Conclusions:

  • Oxygen-ozonetherapy presents a promising new avenue for managing diabetes.
  • The therapy may offer a more effective approach to address vascular damage.
  • Further research and debate are warranted to establish its clinical utility and improve patient outcomes.

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