Hand-biting and hand-waving paroxysms in epilepsy

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Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Marianna Selikhova1, Catherine Scott, Mark Silva

  • 1Department of Movement Disorders, National Hospital for Neurology and Neurosurgery, London, UK. m.selikhova@talk21.com

BMJ Case Reports
|July 21, 2012
PubMed

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
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