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Assessing Activity-based Anorexia in Mice

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5-HTTLPR polymorphism in bulimia nervosa: a multiple-model meta-analysis.

Gina N Polsinelli¹, Robert N Levitan, Vincenzo De Luca

¹Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.

Psychiatric Genetics

|July 21, 2012

Summary

This meta-analysis found no significant link between the serotonin transporter gene (5-HTTLPR) polymorphism and bulimia nervosa (BN). Further research using a triallelic model is recommended to explore this eating disorder association.

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Area of Science:

Genetics
Psychiatry
Neuroscience

Background:

Genes in the serotonergic system are implicated in eating disorder (ED) susceptibility.
Functional polymorphisms of the serotonin transporter gene (5-HTT), specifically the 5-HTTLPR, are suspected contributors to ED pathogenesis.
Previous studies on the association between 5-HTTLPR and bulimia nervosa (BN) have yielded inconsistent results.

Purpose of the Study:

To clarify the association between the 5-HTTLPR polymorphism and BN.
To employ statistical models not utilized in prior meta-analyses.
To incorporate new samples to enhance the scope of previous meta-analyses.

Main Methods:

A comprehensive literature search was conducted across PsychINFO, ISI, and PubMed databases for studies published up to May 2011.
Six case-control samples investigating the 5-HTTLPR polymorphism and BN were included in the meta-analysis.
Data were pooled and analyzed using dominant and additive genetic models.

Main Results:

Both the dominant and additive models revealed a nonsignificant association between the 5-HTTLPR polymorphism and BN.
The findings indicate that this specific polymorphism may not be a primary genetic factor for BN based on current data and models used.
Despite the nonsignificant finding, the role of 5-HTTLPR in the phenotypic variability of psychopathological symptoms in BN patients warrants further investigation.

Conclusions:

The meta-analysis did not establish a significant association between the 5-HTTLPR polymorphism and bulimia nervosa.
The study highlights the need for continued research into the genetic underpinnings of BN.
Future research should explore the 5-HTTLPR polymorphism in BN using the recently proposed triallelic model for a more nuanced understanding.