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Updated: May 20, 2026
09:44
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Radionuclide therapy beyond radioiodine
1Department of Nuclear Medicine and Endocrinology, General Hospital of Linz, Krankenhausstrasse 9, 4021 Linz, Austria. michael.gabriel@akh.linz.at
Wiener Medizinische Wochenschrift (1946)
|July 21, 2012
Summary
Explore advanced radionuclide therapies beyond Iodine-131 for various cancers. This review covers Peptide Receptor Radionuclide Therapy (PRRT), radioimmunotherapy, Yttrium-90 liver treatments, and palliative bone-seeking agents.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiopharmaceutical Therapy
Background:
- Iodine-131 has been a long-standing treatment for thyroid cancer.
- Emerging radiopharmaceuticals offer new therapeutic options for diverse malignant diseases.
- Many new therapies require fewer radiation safety measures than traditional methods.
Purpose of the Study:
- To present four advanced radionuclide therapies gaining prominence in recent years.
- To highlight the application and potential of these novel treatments in oncology.
Main Methods:
- Review of Peptide Receptor Radionuclide Therapy (PRRT) using radiolabeled somatostatin receptor ligands for neuroendocrine tumors.
- Discussion of radioimmunotherapy with radiolabeled anti-CD20 antibodies for malignant lymphoma.
- Overview of Yttrium-90 labeled particle administration for liver tumors.
- Examination of bone-seeking radiopharmaceuticals for palliative care of bone metastases.
Main Results:
- PRRT is effective for neuroendocrine tumors.
- Radioimmunotherapy targets CD20-positive cells in lymphoma.
- Yttrium-90 particles are used for liver malignancies.
- Bone-seeking agents provide palliative relief for bone metastases.
Conclusions:
- Several novel radiopharmaceutical therapies are expanding treatment options in oncology.
- These therapies, including PRRT and radioimmunotherapy, offer targeted approaches for various cancers.
- Radionuclide therapy continues to evolve, providing new avenues for cancer treatment and palliation.
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