MassTRIX reloaded: combined analysis and visualization of transcriptome and metabolome data

Area of Science:

• Systems Biology
• Bioinformatics
• Metabolomics
• Transcriptomics

Background:

• Systems Biology integrates diverse biological data, including genomics, transcriptomics, proteomics, and metabolomics.
• Metabolomics is increasingly incorporated into biological studies, often alongside transcriptomic data.
• Both transcriptomic and metabolomic data provide insights into biological entities and can be mapped onto metabolic pathways.

Purpose of the Study:

• To update the MassTRIX webserver for the joint analysis of transcriptomic and metabolomic data.
• To facilitate the integration of different omics data types for a holistic understanding of biological systems.

Main Methods:

• Utilizing the MassTRIX webserver for integrated analysis.
• Overlaying transcriptomic and metabolomic data onto metabolic pathways.
• Developing updated functionalities for joint data type analysis.

Main Results:

• The MassTRIX webserver has been enhanced to support combined transcriptomic and metabolomic data analysis.
• The updated tool allows for the integration of these two data types for biological interpretation.
• The webserver provides a platform for overlaying omics data onto metabolic pathways.

Conclusions:

• Joint analysis of transcriptomic and metabolomic data provides a more comprehensive view of biological systems.
• The updated MassTRIX webserver facilitates systems biology research by enabling integrated omics data analysis.
• MassTRIX is freely available, promoting accessibility for biological research.