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Retroperitoneal fibrosis.

E S Amis1

  • 1Department of Radiology, Columbia-Presbyterian Medical Center, New York, New York 10032.

Urologic Radiology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Retroperitoneal fibrosis involves fibrotic plaque formation in the lower back, potentially causing ureteral obstruction. While several factors can contribute, most cases of retroperitoneal fibrosis remain idiopathic.

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Area of Science:

  • Nephrology
  • Urology
  • Pathology

Background:

  • Retroperitoneal fibrosis (RPF) is characterized by a fibrotic plaque in the prelumbar/presacral space.
  • Clinical significance arises when RPF causes ureteral obstruction, impacting kidney function.
  • RPF etiology is multifactorial, including drug-induced, inflammatory, post-surgical, and neoplastic causes.

Purpose of the Study:

  • To elucidate the diverse etiologies of retroperitoneal fibrosis.
  • To highlight the clinical implications of ureteral obstruction secondary to RPF.
  • To emphasize the prevalence of idiopathic cases.

Main Methods:

  • Literature review of retroperitoneal fibrosis cases.
  • Analysis of etiological factors associated with RPF.

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  • Clinical significance assessment based on ureteral obstruction.

    • Main Results:

    • RPF can be triggered by medications, fluid collections, intra-abdominal inflammation, surgery, radiation, and metastatic cancers.
    • Ureteral obstruction is a primary clinical manifestation of significant RPF.
    • Idiopathic causes account for the majority of retroperitoneal fibrosis cases.

    Conclusions:

    • Retroperitoneal fibrosis presents with varied causes, necessitating comprehensive diagnostic evaluation.
    • Prompt recognition of ureteral obstruction is crucial for managing RPF.
    • The idiopathic nature of most RPF cases underscores the need for further research into underlying mechanisms.