Sirenomelia: case reports and current concepts of pathogenesis
Minnie Pillay1, Dhanya Yesodharan, Dhanya Lakshmi Narayanan
1Department of Anatomy, Amrita Institute of Medical Sciences and Research Center, Ponekkara, Kerala, India.
Summary
Sirenomelia, a rare congenital anomaly, may result from vascular steal or caudal dysgenesis. This study explores both theories, examining associated defects and genetic factors in two sirenomelia cases.
Area of Science:
- Developmental Biology
- Medical Genetics
- Teratology
Background:
- Sirenomelia is a rare congenital anomaly characterized by fusion of the lower limbs.
- Its pathogenesis is debated, with theories including vascular steal and caudal dysgenesis.
- Sirenomelia is associated with other congenital defects and has implications for genetic counseling.
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