Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Indeterminate Products01:29

Indeterminate Products

Indeterminate forms also arise in the evaluation of limits involving products, particularly when one factor approaches zero while the other tends to positive or negative infinity. This situation, commonly described as a zero-times-infinity form, does not have an immediately interpretable outcome. Depending on how the factors behave relative to one another, the limit of such a product may be zero, infinite, or a finite nonzero value.Product Limits and Algebraic RewritingTo analyze limits of this...
The Buckingham Pi Theorem01:09

The Buckingham Pi Theorem

The Buckingham Pi theorem provides a structured method to simplify fluid dynamics problems by reducing complex systems of variables to dimensionless terms.
Kendall's Tau Test01:16

Kendall's Tau Test

Kendall's tau test, also known as the Kendall rank coefficient test, is a nonparametric method for assessing association between two variables. This test is particularly useful for identifying significant correlations when the distributions of the sample and population are unknown. Developed in 1938 by the British statistician Sir Maurice George Kendall, the tau coefficient (denoted as τ) serves as a rank correlation coefficient, with values ranging from -1 to +1.
A τ value of +1 indicates that...
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Pascal's Law01:04

Pascal's Law

In 1653, the French philosopher and scientist Blaise Pascal published "Treatise on the Equilibrium of Liquids," which discussed the principles of static fluids. A static fluid is a fluid that is not in motion. When a fluid is not flowing, we say that the fluid is in static equilibrium. If the fluid is water, we say it is in hydrostatic equilibrium. For a fluid in static equilibrium, the net force on any part of the fluid must be zero; otherwise, the fluid will start to flow. Pascal observed...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Which assessment tools best distinguish between mild cognitive impairment and dementia? Lessons from a Slovak memory clinic cohort.

BMC geriatrics·2026
Same author

GPATCH11 ortholog Sap34 regulates pre-mRNA splicing by interacting with early spliceosomal complexes in Schizosaccharomyces pombe.

Scientific reports·2026
Same author

<i>Neurospora crassa</i> Δ<i>ccg-8</i> compromises cell surface integrity and antifungal tolerance: Insights from in vitro and <i>Galleria mellonella</i> studies.

Cell surface (Amsterdam, Netherlands)·2026
Same author

Targeting low-grade inflammation in multiple sclerosis through the Wim Hof method or lifestyle intervention: a pilot comparative study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

When Proteins Go MAD-Misfolded, Amplified, Detected: Advances in α-Synuclein Pathophysiology and RT-QuIC Detection.

Molecular neurobiology·2026
Same author

Insights Into the Pathological Glycosylation Associated With COG6-CDG.

Human mutation·2025

Related Experiment Video

Updated: May 20, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

The self-perpetuating tau truncation circle.

Norbert Zilka1, Branislav Kovacech, Peter Barath

  • 1Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava 84510, Slovak Republic.

Biochemical Society Transactions
|July 24, 2012
PubMed
Summary
This summary is machine-generated.

Pathological tau protein truncations are key in neurodegenerative diseases like Alzheimer's. Specific cleavage creates truncated tau species that accelerate tau misfolding and neurofibrillary pathology.

More Related Videos

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
05:51

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons

Published on: May 23, 2019

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

Related Experiment Videos

Last Updated: May 20, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons
05:51

An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons

Published on: May 23, 2019

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pathology

Background:

  • Pathological protein truncations are common in neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease, and Huntington's disease.
  • Truncated tau protein is a major component of neurofibrillary pathology, forming paired helical filaments.
  • Previously identified truncated tau species have distinct molecular signatures, suggesting specific formation mechanisms.

Purpose of the Study:

  • To characterize the pathophysiology of AD-specific truncated tau species.
  • To investigate the role of truncated tau in the progression of Alzheimer's disease pathology.

Main Methods:

  • Utilized a transgenic rat model expressing human truncated tau to study Alzheimer's disease.
  • Analyzed the formation of novel truncated tau species from both transgenic and endogenous tau proteins.
  • Examined the localization of truncated tau proteins within misfolded tau fractions.

Main Results:

  • Expression of human truncated tau in rats induced the formation of new truncated tau species.
  • These novel truncated tau species were derived from both human and endogenous rat tau.
  • Truncated tau proteins were exclusively found in the misfolded tau fraction, indicating active participation in tau misfolding.

Conclusions:

  • Tau truncation is a specific process, not random, involving proteolytic cleavage or fragmentation.
  • Truncated tau species actively contribute to the tau misfolding process.
  • The emergence of truncated tau initiates a self-perpetuating cycle that accelerates tau misfolding and neurofibrillary pathology in Alzheimer's disease.