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Alternatively folded proteins with unexpected beneficial functions

Soyoung Min1, James Meehan, Louise M Sullivan

  • 1Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland.

Biochemical Society Transactions
|July 24, 2012
PubMed
Summary

Human α-lactalbumin made lethal to tumour cells (HAMLET) and its complexes are novel nanoparticles with selective tumor cell toxicity. Partially unfolded proteins are key, enabling alternative functions and targeting tumor cell death pathways.

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