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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Updated: May 20, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Long non-coding RNAs and human disease.

Lorna W Harries1

  • 1Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, Exeter, UK. L.W.Harries@exeter.ac.uk

Biochemical Society Transactions
|July 24, 2012
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are key regulatory molecules fine-tuning gene expression. This review explores their diverse mechanisms, cellular roles, and links to human diseases.

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

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Last Updated: May 20, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Area of Science:

  • Molecular Biology
  • Genomics
  • Gene Regulation

Background:

  • The central dogma describes DNA to RNA to protein, but 50% of the transcriptome is non-coding.
  • Small regulatory RNAs (microRNAs, siRNAs) are well-defined, unlike long non-coding RNAs (lncRNAs).
  • lncRNAs are pervasive eukaryotic transcripts regulating gene expression through epigenetic control, chromatin status, mRNA processing, and translation.

Purpose of the Study:

  • To review the potential mechanisms of action for lncRNAs.
  • To outline cellular processes associated with lncRNA function.
  • To explore emerging evidence linking lncRNAs to human diseases.

Main Methods:

  • Literature review of lncRNA research.
  • Analysis of lncRNA regulatory mechanisms.
  • Synthesis of evidence for lncRNA involvement in disease.

Main Results:

  • lncRNAs act through diverse mechanisms including epigenetic modification and mRNA processing.
  • lncRNAs are implicated in fundamental cellular processes.
  • Growing evidence suggests lncRNA dysregulation contributes to human diseases.

Conclusions:

  • lncRNAs represent a critical, understudied class of gene regulators.
  • Understanding lncRNA function is crucial for deciphering gene expression and disease pathogenesis.
  • Further research into lncRNAs holds promise for novel therapeutic strategies.