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Related Concept Videos

Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Updated: May 20, 2026

Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity
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Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity

Published on: October 22, 2018

Non-coding RNAs in Saccharomyces cerevisiae: what is the function?

Jian Wu1, Daniela Delneri, Raymond T O'Keefe

  • 1Faculty of Life Sciences, University of Manchester, Manchester, UK.

Biochemical Society Transactions
|July 24, 2012
PubMed
Summary

Recent studies reveal pervasive transcription in eukaryotes, producing many non-coding RNAs (ncRNAs). This review explores newly identified functional ncRNAs in Saccharomyces cerevisiae and their roles in gene regulation.

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Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity
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Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using &#967;CRAC
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Monitoring Protein-RNA Interaction Dynamics In Vivo at High Temporal Resolution Using χCRAC

Published on: May 9, 2020

Area of Science:

  • Genomics
  • Molecular Biology
  • Yeast Genetics

Background:

  • Advanced sequencing and microarray technologies reveal widespread transcription in eukaryotes.
  • A significant portion of transcribed RNAs lack coding capacity, termed non-coding RNAs (ncRNAs).
  • The functional relevance of these ncRNAs is a key area of ongoing scientific investigation.

Purpose of the Study:

  • To review recent discoveries concerning ncRNAs in the yeast Saccharomyces cerevisiae.
  • To highlight newly identified ncRNAs in this model organism.
  • To discuss the potential functions and regulatory mechanisms of these ncRNAs.

Main Methods:

  • Literature review of recent studies on yeast ncRNAs.
  • Analysis of data from high-resolution microarray and next-generation sequencing.
  • Functional characterization of identified ncRNAs.

Main Results:

  • Identification of novel ncRNAs in Saccharomyces cerevisiae.
  • Evidence suggesting functional roles for these ncRNAs in gene regulation.
  • Elucidation of potential molecular mechanisms underlying ncRNA activity.

Conclusions:

  • Saccharomyces cerevisiae possesses a diverse repertoire of functional ncRNAs.
  • These ncRNAs play significant roles in regulating gene expression.
  • Further research is needed to fully understand the ncRNA landscape and its impact on cellular processes.