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[Studies on streptomycin albumin microspheres for injection]
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1990
Summary
Polymeric dispersing agents created streptomycin albumin microspheres (10-30 microns) for drug delivery. Intravenous injection in rats showed lung accumulation, with effectiveness and side effects pending further study.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Engineering
Context:
- Microsphere drug delivery systems offer potential for targeted therapies.
- Albumin-based microspheres are investigated for controlled drug release and tissue distribution.
Purpose:
- To prepare and characterize streptomycin albumin microspheres using polymeric dispersing agents.
- To evaluate the in vivo tissue distribution of these microspheres after intravenous administration.
Summary:
- Streptomycin albumin microspheres were successfully prepared with diameters ranging from 10 to 30 microns and a drug content of 20.3 ± 0.5%.
- In vivo studies using fluorescein isothiocyanate and 125I labeled microspheres in rats demonstrated significant accumulation in the lungs post-intravenous injection.
- Drug release kinetics were assessed using a dynamic dialysis system.
Impact:
- This research provides foundational data on the physical properties and biodistribution of streptomycin albumin microspheres.
- The findings suggest potential for lung-targeted delivery of streptomycin via albumin microspheres.
- Further investigation is required to determine the therapeutic efficacy and safety profile of this drug delivery system.