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Prevalence of symptomatic intracranial atherosclerosis in Caucasians: a prospective, multicenter, transcranial

Georgios Tsivgoulis1, Konstantinos Vadikolias, Ioannis Heliopoulos

  • 1Department of Neurology, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece; Second Department of Neurology, School of Medicine, University of Athens, Attikon Hospital, Athens, Greece.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|July 24, 2012
PubMed

Insights

Symptomatic intracranial atherosclerosis (SIA) affects nearly 10% of Caucasian patients hospitalized with acute cerebral ischemia. Key risk factors include diabetes and hypertension, highlighting the need for improved detection strategies.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Diagnostic Imaging

Background:

  • Limited data exists on symptomatic intracranial atherosclerosis (SIA) prevalence in Caucasian populations.
  • Acute cerebral ischemia (ACI) is a significant health concern with various underlying causes.

Purpose of the Study:

  • To investigate the prevalence of SIA in Caucasian patients hospitalized with ACI.
  • To identify risk factors associated with SIA in this demographic.

Main Methods:

  • Prospective, multicenter Transcranial Doppler sonography (TCD) study.
  • Inclusion of consecutive ACI patients over 24 months.
  • Diagnosis of >50% intracranial stenosis using SONIA trial criteria, confirmed by angiography (MRA/CTA) and evidence of cerebral infarction.

Main Results:

  • SIA was identified in 9.2% of 467 ACI patients (43 individuals).
  • The most frequent locations for SIA were M1MCA (34.9%) and TICA (18.8%).
  • Diabetes mellitus (OR: 4.25) and hypertension (OR: 2.41) were independently associated with SIA.

Conclusions:

  • SIA prevalence is nearly 10% in Caucasian patients with ACI.
  • Findings suggest a need for enhanced collaborative efforts among stroke physicians for SIA detection.
  • Further research may refine diagnostic yield and management strategies for SIA in Caucasian ACI patients.
Abstract

Keywords:
CaucasiansTCDintracranial atherosclerosis

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