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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

[Localised prostate cancer: the PREFERE trial].

Michael Stöckle¹, Roswitha Bussar-Maatz

¹Klinik für Urologie und Kinderurologie der Universität des Saarlandes, Homburg an der Saar.

Zeitschrift Fur Evidenz, Fortbildung Und Qualitat Im Gesundheitswesen

|July 24, 2012

Summary

A new trial will compare four prostate cancer treatments: surgery, radiotherapy, seed implantation, and active surveillance. This study aims to determine the best approach for localized prostate cancer, improving patient outcomes.

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Area of Science:

Oncology
Urology
Clinical Trials

Background:

Prostate cancer is a leading cause of cancer mortality in elderly men.
Improved diagnostics and PSA screening have led to earlier detection of prognostically diverse tumor stages.
Current treatment guidelines recommend radical prostatectomy, radiotherapy, seed implantation, and active surveillance for localized disease.

Purpose of the Study:

To compare the efficacy and outcomes of four guideline-recommended treatments for localized prostate cancer.
To provide evidence-based data for treatment decisions in localized prostate cancer.
To evaluate radical prostatectomy, percutaneous radiotherapy, permanent seed implantation, and active surveillance.

Main Methods:

A prospective, randomized, multicenter trial.
Comparison of four treatment options for localized prostate cancer.
Allows for the rejection of one or two treatment options based on trial arms.

Main Results:

The trial is designed to generate comparative data on the four main treatment modalities.
Results will inform clinical decision-making for localized prostate cancer.
Expected to provide insights into the relative effectiveness of different treatment strategies.

Conclusions:

The study will establish a comparative evidence base for localized prostate cancer treatments.
Findings will guide the selection of optimal treatment strategies.
Aims to improve patient management and outcomes in prostate cancer care.