Related Experiment Video
Updated: May 20, 2026
05:39
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Do transfusions cause necrotizing enterocolitis? The complementary role of randomized trials and observational
Haresh Kirpalani1, John A F Zupancic
1Division of Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4399, USA. kirpalanih@email.chop.edu
Seminars in Perinatology
|July 24, 2012
Summary
Newborn transfusions may be linked to necrotizing enterocolitis. This review examines observational and randomized studies, suggesting randomized trials are crucial for confirming such associations.
Area of Science:
- Neonatal medicine
- Hematology
- Gastroenterology
Background:
- Necrotizing enterocolitis (NEC) is a serious condition in newborns.
- The potential association between blood transfusions and NEC has been explored.
- Existing literature includes both observational and randomized trial data.
Purpose of the Study:
- To systematically review and meta-analyze studies on transfusion-associated necrotizing enterocolitis (TA-NEC).
- To compare findings from randomized trials versus observational studies.
- To propose a framework for evaluating such associations.
Main Methods:
- Systematic review of published literature.
- Meta-analysis of relevant studies.
- Comparative analysis of study designs (randomized trials vs. observational studies).
Main Results:
- Observational studies have suggested a link between newborn transfusions and NEC.
- Randomized trials provide a different perspective on this association.
- Discrepancies between study types highlight the need for rigorous evaluation.
Conclusions:
- Observational studies are valuable for hypothesis generation regarding transfusion risks.
- Randomized controlled trials are essential for definitive testing of these hypotheses.
- The association between neonatal transfusions and NEC is amenable to randomized evaluation.
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