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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

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Related Experiment Video

Updated: May 20, 2026

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
04:12

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Published on: January 19, 2024

Compounding as a current therapeutic option in dermatology.

M Sánchez-Regaña1, F Llambí-Mateos, M Salleras-Redonnet

  • 1Servicio de Dermatología, Hospital Universitari Sagrat Cor, Barcelona, España.

Actas Dermo-Sifiliograficas
|July 24, 2012
PubMed
Summary

Compounding remains a valuable tool for treating skin conditions, offering personalized treatments when commercial products are insufficient. This review explores its benefits, drawbacks, and evolving role in dermatology.

Keywords:
Active ingredientCompoundingDermatologic preparationDermatologic therapyFormulación magistralPreparado dermatológicoPrincipio activoTerapia dermatológicaVehicleVehículo

Related Experiment Videos

Last Updated: May 20, 2026

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
04:12

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Published on: January 19, 2024

Area of Science:

  • Dermatology
  • Pharmaceutical Sciences

Background:

  • Compounding historically played a crucial role in dermatology for treating conditions lacking specific pharmaceutical products.
  • Its importance diminished with the rise of commercial drugs, raising concerns about safety, stability, and efficacy.
  • Compounding is now regaining prominence in routine dermatological practice.

Purpose of the Study:

  • To review the advantages and disadvantages of dermatological compounding.
  • To outline common indications for compounded therapies.
  • To discuss current legislation and recent advancements in compounded active ingredients and vehicles.

Main Methods:

  • Literature review of compounding in dermatology.
  • Analysis of current legislative frameworks.
  • Survey of recent developments in dermatological compounding ingredients and vehicles.

Main Results:

  • Compounding offers personalized treatment options and addresses unmet needs in dermatological care.
  • Key indications include inflammatory skin diseases, infections, and cosmetic concerns.
  • Recent advancements focus on novel active ingredients and improved vehicle formulations for enhanced delivery and stability.

Conclusions:

  • Compounding is a vital and evolving aspect of dermatological treatment, offering tailored solutions.
  • Understanding its benefits, limitations, and regulatory landscape is essential for effective clinical application.
  • Continued research into new ingredients and vehicles will further enhance its utility.