Related Experiment Video
Updated: May 20, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
Platelet serotonin in primary Sjögren's syndrome: level and relation with disease activity
Helena Sarac1, Jasenka Markeljevic, Gordana Mokrovic
1Department of Neurology, University Hospital Centre Zagreb and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, HR-10000 Zagreb, Croatia.
Abstract:
Primary Sjögren's syndrome (pSS) is chronic autoimmune disorder of unknown ethiopathogenesis. In line with the concept of neuroimmunohormonal dysregulation in inflammatory rheumatic diseases, the aim of this study was to investigate platelet serotonin level (PSL) in patients with pSS and its relation with the activity and duration of the disease. Significantly lower PSL in pSS patients (N=61) was shown as compared to healthy controls (N=103). No correlation was found between PSL and the actual disease activity assessed by the recently developed EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI). Results suggest involvement of the serotonin system in the pathogenesis of pSS.
Related Concept Videos
Myasthenia Gravis ll: Pathophysiology
Graves Disease II: Pathophysiology
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inflammatory Bowel Disease IV: Clinical Manifestations
Nephrotic Syndrome II : Assessment and Medical Management
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
