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Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged
Jane McEneny1, Lauren Wade, Ian S Young
1Centre for Public Health, Queen's University Belfast, BT12 6BJ, UK. j.mceneny@qub.ac.uk
The Journal of Nutritional Biochemistry
|July 24, 2012
Summary
Increased lycopene intake, through diet or supplements, reduced inflammation and improved HDL functionality in overweight adults. These findings suggest lycopene offers heart-protective benefits by enhancing antiatherogenic properties.
Area of Science:
- Nutrition Science
- Cardiovascular Health
- Biochemistry
Background:
- Overweight individuals benefit from interventions reducing inflammation.
- Observational studies link antioxidants to reduced cardiovascular risk.
- Direct evidence on antioxidant effects on inflammation is limited.
Purpose of the Study:
- To investigate lycopene's impact on systemic and HDL-associated inflammation.
- To assess lycopene's influence on HDL functionality in overweight adults.
Main Methods:
- 54 moderately overweight, middle-aged subjects received control, lycopene-rich diet, or lycopene supplement for 12 weeks.
- Serum amyloid A (SAA) measured systemic and HDL-associated inflammation.
- HDL functionality assessed via paraoxonase-1 (PON-1), CETP, and LCAT activities.
Main Results:
- Lycopene intake increased serum and HDL lycopene levels.
- SAA decreased in serum and HDL(3) with lycopene interventions.
- Lycopene enhanced HDL functionality by increasing PON-1 and LCAT activities and decreasing CETP activity.
Conclusions:
- Lycopene intake positively modulates HDL properties, potentially enhancing antiatherogenic functions.
- Increased lycopene intake demonstrates heart-protective effects in overweight individuals.
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