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[The morphological changes in the wall of the carotid and vertebral arteries in pathological kinks and loops]
Insights
Degenerative arterial changes in carotid and vertebral arteries are linked to hemodynamic stress, suggesting congenital origins for some kinks. Age and hypertension contribute to others.
Area of Science:
- Vascular Surgery
- Neurology
- Pathology
Background:
- Pathologic coiling and kinking of the carotid and vertebral arteries can lead to significant cerebrovascular events.
- Understanding the etiology of these arterial abnormalities is crucial for effective clinical management.
Purpose of the Study:
- To investigate the underlying causes of pathologic coiling and kinking in the carotid and vertebral arteries.
- To differentiate between congenital and acquired etiologies of these arterial configurations.
Main Methods:
- Analysis of clinical data from 1300 patients undergoing angiographic examination.
- Review of surgical records for 738 patients who underwent operations for arterial coiling.
- Histologic examination of 50 resected arterial segments with pathologic changes.
Main Results:
- Significant degenerative changes were observed in the arterial walls at sites of loops and kinks.
- Hemodynamic overload was identified as a primary factor contributing to these degenerative changes.
- Evidence suggests a congenital origin for many observed loops and certain kinks.
- Other kinks were associated with aging, cervical osteochondrosis, and hypertension.
Conclusions:
- Hemodynamic overload contributes to degenerative arterial changes in carotid and vertebral arteries.
- Congenital factors likely play a role in the development of arterial loops and some kinks.
- Age-related changes, cervical spine issues, and hypertension are implicated in acquired arterial kinks.
Abstract:
The clinical data (1300 patients angiographically examined and 738 operations performed for pathologic coiling of the carotid and vertebral arteries) together with histologic studies of 50 resected segments of pathologically changed arteries showed the considerable degenerative changes in the arterial wall at the site of the loops and kinks, caused by the hemodynamic overload. The data suggest the congenital nature of the loops and certain kinks of the carotid and vertebral arteries. Other kinks of these arteries result from changes associated with age, osteochondrotic shortening of the cervical vertebral column and arterial hypertension.