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Updated: May 20, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Human ocular biometry.

Robert C Augusteyn1, Derek Nankivil, Ashik Mohamed

  • 1Vision Cooperative Research Centre, Brien Holden Vision Institute, Sydney, Australia. B.Augusteyn@ier.org.au

Experimental Eye Research
|July 24, 2012
PubMed
Summary
This summary is machine-generated.

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Human eye globe and cornea dimensions grow rapidly during prenatal development, reaching maximum size shortly after birth. Postnatal growth ceases within the first year, with no significant differences observed between sexes.

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Human Anatomy

Background:

  • Understanding ocular development is crucial for diagnosing and managing various eye conditions.
  • Previous research has provided insights into eye growth, but comprehensive data across the entire lifespan is limited.

Purpose of the Study:

  • To meticulously document the growth patterns of the human eye globe and cornea from gestation through adulthood.
  • To establish normative data for key ocular dimensions throughout human development.

Main Methods:

  • Digital calipers (±0.01 mm) were used to measure antero-posterior length, horizontal/vertical diameters of the globe, and horizontal/vertical white-to-white corneal diameters in 541 postmortem eyes.
  • Data from existing literature were integrated for pre- and postnatal dimensions.

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Last Updated: May 20, 2026

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  • Logistic analysis was employed to model growth patterns.

    • Main Results:

    • All measured ocular dimensions exhibited rapid prenatal growth, stabilizing shortly after birth.
    • Globe and corneal growth ceased within approximately one year post-birth, indicating an asymptotic prenatal growth mode.
    • No statistically significant differences in ocular dimensions were found between males and females at any age.

    Conclusions:

    • Human eye globe and cornea growth are predominantly prenatal, reaching adult dimensions within the first year of life.
    • The cessation of a growth-stimulating signal around birth likely marks the end of the primary growth phase.
    • Ocular dimensions are consistent between sexes, suggesting a common developmental trajectory.