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Slide Preparation Method to Preserve Three-dimensional Chromatin Architecture of Testicular Germ Cells
07:34

Slide Preparation Method to Preserve Three-dimensional Chromatin Architecture of Testicular Germ Cells

Published on: January 10, 2014

Chromatin associated Sin3A is essential for male germ cell lineage in the mouse

Jessica Pellegrino1, Diego H Castrillon, Gregory David

  • 1Department of Biochemistry and Molecular Pharmacology, New York University Langone Medical Center, NY, USA.

Developmental Biology
|July 24, 2012
PubMed

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The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
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The Ratio of X Chromosome to Autosomes

In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
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