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Evaluation of a method for the simultaneous detection of multiple tumor markers using a multiplex suspension bead
Yajie Wang1, Fang Fang, Congning Shi
1Laboratory of Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, No. 6, Tiantan Xili, Dongcheng District, Beijing 100050, PR China.
Objective:
To achieve higher tumor detection efficiency, we evaluated a multiplex assay for TM analysis based on the Luminex-100 multiplex suspension bead array.
Design:
The assay simultaneously determined the concentrations of nine TMs in 1114 human serum specimens (546 patients with tumors, 158 patients with non-tumor inflammatory diseases, and 410 normal controls). The nine TMs were AFP, CEA, CA125, CYFRA 21-1, CA242, f-PSA, t-PSA, NSE and free β-hCG. The multiplex suspension bead assays were compared with conventional methods used in clinical laboratories.
Results:
The Luminex assay has the same levels of sensitivity, specificity and accuracy in the prediction of positive tumor specimens as conventional methods.
Conclusion:
Multiplex suspension bead arrays have promising applications in clinical laboratories.
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