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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
What is the Immune System?01:38

What is the Immune System?

Overview
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: May 20, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Immune deficiency and autoimmunity.

Thomas Prescott Atkinson1

  • 1University of Alabama at Birmingham, Birmingham, Alabama, USA. patkinson@peds.uab.edu

Current Opinion in Rheumatology
|July 24, 2012
PubMed
Summary
This summary is machine-generated.

Primary immunodeficiencies and autoimmunity share complex genetic links. Understanding these connections, including how immune defects cause autoimmunity or vice versa, improves diagnosis and treatment.

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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Related Experiment Videos

Last Updated: May 20, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

  • Immunology
  • Genetics
  • Autoimmunity

Background:

  • Primary immunodeficiencies (PIDs) are genetic disorders impairing the immune system.
  • Autoimmunity involves the immune system attacking the body's own tissues.
  • A significant overlap exists between PIDs and autoimmune diseases.

Purpose of the Study:

  • To review the intricate mechanisms linking PIDs and autoimmunity.
  • To elucidate how genetic defects can lead to both immune deficiency and self-tolerance loss.
  • To explore novel pathways where autoimmunity can cause immunodeficiency.

Main Methods:

  • Literature review of recent research on PIDs and autoimmunity.
  • Analysis of genetic defects and their impact on immune regulation.
  • Examination of T-cell function and cytokine-mediated autoimmunity.

Main Results:

  • Shared genetic defects can cause PIDs and autoimmunity.
  • Impaired regulatory T-cell function is a common pathway to autoimmunity in PIDs.
  • Autoimmunity can manifest as immunodeficiency through antibody production against cytokines.

Conclusions:

  • The relationship between PIDs and autoimmunity is complex and bidirectional.
  • Understanding these mechanisms offers insights into pathogenesis.
  • This knowledge can lead to improved diagnostic and therapeutic strategies for patients.