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Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis
Published on: November 14, 2025
Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes
David G Smith1, Brian K McMahon, Robert Pal
1Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK.
Chemical Communications (Cambridge, England)
|July 24, 2012
Abstract:
Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes.
