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Related Concept Videos

The Replisome03:01

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...
The Replisome03:01

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...
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The paradox
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The Nucleosome Core Particle01:12

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species
14:33

Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species

Published on: August 30, 2012

The Core Diseasome.

Vuk Janjić1, Nataša Pržulj

  • 1Department of Computing, Imperial College London, London, SW7 2AZ, UK. natasha@imperial.ac.uk

Molecular Biosystems
|July 24, 2012
PubMed
Summary
This summary is machine-generated.

Researchers identified a "Core Diseasome" subnetwork within the human protein-protein interaction (PPI) network. This core network is computationally derived and crucial for understanding disease formation and therapeutic targets.

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Area of Science:

  • Systems biology
  • Network medicine
  • Computational biology

Background:

  • Extensive protein-protein interaction (PPI) data reveals a non-random human PPI network structure.
  • Network topology is linked to biological processes and disease etiology.

Purpose of the Study:

  • To identify a disease-centric subnetwork within the human PPI network.
  • To investigate if this subnetwork's topology is key to disease formation and therapeutic intervention.

Main Methods:

  • Computational analysis of the human PPI network.
  • Successive pruning of the PPI network to isolate a core subnetwork.
  • Topological and functional characterization of the identified subnetwork.

Main Results:

  • A topologically and functionally homogeneous "Core Diseasome" subnetwork was identified.
  • The Core Diseasome is enriched in disease genes, drug targets, and disease-driving genes.
  • The unique topology of the Core Diseasome suggests its critical role in disease mutagenesis.

Conclusions:

  • A specific subnetwork, the Core Diseasome, plays a pivotal role in disease development.
  • The topology of the Core Diseasome may govern mutagenesis leading to disease.
  • Further research is needed to elucidate mechanisms and therapeutic applications.