Assessment of median nerve with MR neurography by using diffusion-tensor imaging: normative and pathologic diffusion...

Area of Science:

• Neuroimaging
• Medical Physics

Background:

• Carpal tunnel syndrome (CTS) is a common condition affecting the median nerve.
• Accurate diagnostic methods for CTS are crucial for effective treatment.

Purpose of the Study:

• To establish normative diffusion values for the median nerve in healthy individuals.
• To compare these values with those in patients diagnosed with carpal CTS.
• To assess the influence of age, sex, and anatomical location on these diffusion metrics.

Main Methods:

• Magnetic resonance (MR) neurography with diffusion-tensor imaging (DTI) was performed on 45 healthy volunteers and 15 CTS patients.
• Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured at three distinct anatomical locations along the median nerve.
• Data were analyzed to determine normative values and compare between healthy and patient groups, considering age and sex.

Main Results:

• Median nerve FA and ADC values showed significant variations with anatomical location and age.
• FA decreased, while ADC increased, from proximal to distal nerve segments and with advancing age.
• Significant differences in FA and ADC were observed between healthy individuals and CTS patients, suggesting diagnostic potential.

Conclusions:

• Normative diffusion values of the median nerve are influenced by anatomical site and age, but not by sex.
• Age-specific thresholds for FA and ADC show promise for the objective diagnosis of carpal tunnel syndrome.