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Facile Preparation of (2Z,4E)-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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What differs on the enzymatic acetylation mechanisms for arylamines and arylhydrazines substrates? A theoretical

Qing-An Qiao1, Xiao-Min Sun, Jie Jing

  • 1School of Chemistry and Materials Science, Ludong University, Yantai 264025, China.

Research Letters in Biochemistry
|July 24, 2012
PubMed

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Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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Basicity of Heterocyclic Aromatic Amines

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