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Updated: May 20, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

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Published on: August 9, 2012

Alloplastic bladder substitution: are we making progress?

Marco Cosentino¹, Josep M Gaya, Alberto Breda

¹Department of Urology, Fundació Puigvert, Universitat Autonoma de Barcelona, c/Cartagena 340, 08025 Barcelona, Spain. doccosentino@gmail.com

International Urology and Nephrology

|July 24, 2012

Summary

This summary is machine-generated.

Radical cystectomy for bladder cancer often involves bowel complications. This review explores the history and potential of artificial bladder substitutes as an alternative to intestinal reconstruction.

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Area of Science:

Urology
Biomaterials Science
Surgical Innovation

Background:

Radical cystectomy is standard for muscle-invasive bladder cancer.
Urinary diversion using bowel segments causes significant morbidity.
Alternatives to bowel reconstruction are sought to improve patient outcomes.

Purpose of the Study:

To review the historical development of alloplastic bladder substitution.
To summarize proposed artificial bladder prostheses.
To highlight future directions in bladder replacement technology.

Main Methods:

Comprehensive literature review using Medline and Google Scholar.
Keywords included cystectomy, bladder substitution, artificial bladder, alloplastic material, and tissue engineering.
Analysis of historical and proposed bladder prostheses.

Main Results:

Various alloplastic bladder prostheses have been proposed since 1959.
Silicone has been the most frequently used material.
The last proposed model was described in 1996.

Conclusions:

Alloplastic bladder substitution remains an area of research.
Advances in biomaterials and tissue engineering offer future potential.
Interprofessional collaboration is crucial for developing effective artificial bladders.