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[Bone substitute. Transplants and replacement materials--an update].

C Rentsch1, B Rentsch, D Scharnweber

  • 1Klinik und Poliklinik für Unfall- und Wiederherstellungschirurgie, Universitätsklinikum Carl Gustav Carus Dresden, Fetscherstraße 74, 01307, Dresden. claudia.rentsch@uniklinikum-dresden.de

Der Unfallchirurg
|July 24, 2012
PubMed
Summary
This summary is machine-generated.

Autologous bone is the gold standard for bone grafting. This review details available bone substitutes, their classifications, and future tissue engineering and gene therapy prospects.

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Last Updated: May 20, 2026

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Context:

  • Autologous bone grafts are the gold standard for bone defect repair.
  • The market offers numerous bone substitutes, making an overview challenging.
  • Understanding these alternatives is crucial for effective clinical application.

Purpose:

  • To provide a comprehensive review of currently available bone substitutes.
  • To classify bone substitutes based on origin, vitality, biological priority, and composition.
  • To discuss the advantages and disadvantages of individual bone graft materials.

Summary:

  • This paper reviews various bone substitutes used in bone grafting procedures.
  • It explores different classification systems and analyzes individual materials.
  • The review covers materials like allografts and synthetic bone substitutes.
  • Advantages and disadvantages of each material are detailed.

Impact:

  • Facilitates informed selection of bone graft materials for clinical practice.
  • Highlights the limitations of current bone substitutes.
  • Provides insight into future directions in bone regeneration, including tissue engineering and gene therapy.