Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

4.8K
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
4.8K
Proteoglycans01:05

Proteoglycans

4.6K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
4.6K
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

7.6K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
7.6K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

6.4K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
6.4K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.1K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.1K
Glycosaminoglycans01:23

Glycosaminoglycans

6.7K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney" [Matrix Biology 68-69 (2018) 293-317].

Matrix biology : journal of the International Society for Matrix Biology·2026
Same author

Corrigendum to "Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury." Kidney International 2019;95:540-562.

Kidney international·2026
Same author

Inhibition of FXIIa attenuates kidney fibrosis in mice with unilateral ureteral obstruction.

Cellular and molecular life sciences : CMLS·2025
Same author

The Powerful Impact of Interdisciplinary Collaboration Between Societies.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2025
Same author

Challenges in mimicking hypoxia: insights into HIF-regulated MiRNA expression induced by DMOG and CoCl<sub>2</sub>.

Cell communication and signaling : CCS·2025
Same author

Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.

American journal of physiology. Cell physiology·2025

Related Experiment Video

Updated: Jan 4, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

4.0K

Biglycan: a multivalent proteoglycan providing structure and signals.

Madalina V Nastase1, Marian F Young, Liliana Schaefer

  • 1Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany.

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
|July 24, 2012
PubMed
Summary

Biglycan, an extracellular matrix component, acts as a danger signal that triggers inflammation and influences bone and muscle health. This research explores its dual role in immunity and the musculoskeletal system.

More Related Videos

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
14:02

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

13.0K
Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

11.1K

Related Experiment Videos

Last Updated: Jan 4, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
11:21

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

4.0K
Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
14:02

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

13.0K
Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

11.1K

Area of Science:

  • Biochemistry
  • Immunology
  • Cell Biology

Background:

  • Biglycan is a structural component of the extracellular matrix (ECM).
  • Recent research suggests biglycan also functions as a signaling molecule.
  • Released biglycan signals tissue stress or injury, activating innate immunity.

Purpose of the Study:

  • To summarize recent findings on biglycan's role in inflammation and the musculoskeletal system.
  • To highlight biglycan's dual function as a structural and signaling molecule.
  • To explore biglycan's therapeutic potential for inflammatory and musculoskeletal diseases.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of biglycan's interactions with innate immunity receptors and inflammasomes.
  • Examination of biglycan's tissue-specific roles in bone, muscle, and neuromuscular junctions.

Main Results:

  • Biglycan acts as a danger signal, activating proinflammatory signaling pathways.
  • It links innate and adaptive immunity by clustering cell surface receptors.
  • Biglycan is crucial for bone formation, muscle integrity, and neuromuscular junction stability.

Conclusions:

  • Biglycan possesses both structural and signaling functions.
  • It plays a significant role in regulating inflammation and maintaining musculoskeletal health.
  • Biglycan presents a potential therapeutic target for inflammatory diseases and muscular dystrophies.