Related Experiment Video
Updated: May 20, 2026
07:38
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Overdose of pegfilgrastim: case report
Gisela Riu1, Anna Estefanell, Meritxell Nomdedeu
1Pharmacy Service, Hospital Clínic de Barcelona, c/Villarroel, 170, Escalera 8 sótano, 08036 Barcelona, Spain. gisbcn@hotmail.com
International Journal of Clinical Pharmacy
|July 24, 2012
Summary
A patient with T-cell lymphoma received an accidental pegfilgrastim overdose during chemotherapy. Close monitoring revealed no adverse effects, suggesting this is key for managing pegfilgrastim overdose.
Area of Science:
- Oncology
- Pharmacology
Background:
- Pegfilgrastim is a granulocyte-colony stimulating factor (G-CSF) used in single doses post-chemotherapy.
- It supports neutrophil recovery, reducing infection risk in cancer patients.
Observation:
- A 59-year-old male with Stage III-B CD4+ peripheral T-cell lymphoma received CHOP-14 chemotherapy.
- An error resulted in four consecutive daily doses of pegfilgrastim instead of the intended single dose.
- The patient was hospitalized for observation following the overdose.
Findings:
- The patient exhibited no significant symptoms or laboratory abnormalities during the three days post-pegfilgrastim administration.
- Discharge occurred without immediate complications related to the overdose.
Implications:
- This case highlights the importance of vigilant patient monitoring in instances of pegfilgrastim overdose.
- Available literature supports close observation as the primary management strategy for accidental pegfilgrastim overdosage.
Related Concept Videos
01:30Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
01:16Drug toxicity: Idiosyncratic Reactions
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
01:21Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
01:24Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
01:00Drug Toxicity: Overview
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
01:26Pharmaceutical Poisoning: Potential Scenarios
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...