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[Pharmacological studies on dingchuanning].

J Huang1, P Xu, Z Zhang

  • 1Jiangxi College of Traditional Chinese Medicine, Nanchang.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|November 1, 1990
PubMed
Summary
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Dingchuanning enhances lung perfusion and relaxes airway smooth muscles in guinea pigs. This compound demonstrates protective effects against asthma, acting as an expectorant and inhibiting SRS-A release.

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Preclinical Research

Background:

  • Asthma is a chronic respiratory disease characterized by airway inflammation and bronchoconstriction.
  • Bronchoconstrictors and anaphylaxis trigger airway smooth muscle contraction, leading to asthma symptoms.
  • Slow-reacting substance of anaphylaxis (SRS-A) plays a crucial role in mediating bronchoconstriction and inflammation in asthma.

Purpose of the Study:

  • To investigate the pharmacological effects of Dingchuanning on respiratory function in isolated guinea-pig models.
  • To evaluate the potential of Dingchuanning as a therapeutic agent for bronchial asthma and related respiratory conditions.

Main Methods:

  • Assessment of lung perfusion in isolated guinea-pig lungs.
  • In vitro studies on isolated trachea, bronchus, and lung strips to determine smooth muscle relaxant properties.

Related Experiment Videos

  • In vivo evaluation of protective effects against experimentally induced bronchial asthma in conscious guinea-pigs.
  • Measurement of expectorant and antianaphylactic activities.
  • Analysis of the compound's effect on slow-reacting substance of anaphylaxis (SRS-A) release and activity.

    • Main Results:

    • Dingchuanning significantly increased lung perfusion in isolated guinea-pig lungs.
    • The compound exhibited a notable relaxing effect on the smooth muscles of the isolated trachea, bronchus, and lung strips.
    • Dingchuanning demonstrated a prominent protective effect against induced bronchial asthma in conscious guinea-pigs.
    • Significant expectorant and antianaphylactic effects were observed.
    • The compound markedly inhibited SRS-A release from lung tissues and directly counteracted SRS-A activity.

    Conclusions:

    • Dingchuanning possesses significant bronchodilatory and anti-asthmatic properties.
    • Its mechanisms of action include smooth muscle relaxation, inhibition of SRS-A release, and direct antagonism of SRS-A.
    • These findings suggest Dingchuanning as a potential therapeutic candidate for managing respiratory diseases like asthma.