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Updated: May 20, 2026
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Ganglioside Extraction, Purification and Profiling
Published on: March 12, 2021
A chemoenzymatic total synthesis of the neurogenic starfish ganglioside LLG-3 using an engineered and evolved
Jamie R Rich1, Stephen G Withers
1Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada. jrich@chem.ubc.ca
Angewandte Chemie (International Ed. in English)
|July 24, 2012
Abstract:
An LLG-3 oligosaccharide-fluoride can be assembled chemoenzymatically and readily coupled with various sphingosines by an engineered endoglycoceramidase glycosynthase. The lyso-ganglioside products are acylated to generate the individual isomers identified in the heterogeneous natural isolates, as well as modified glycosphingolipids.
