Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 20, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Biodegradable composites with aligned hydroxyapatite nanoneedles.

Shih-Po Sun1, Mei Wei, James R Olson

  • 1Polymer Program, Institute of Materials Science, University of Connecticut, Connecticut, USA. tobersun@moldex3d.com

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|July 24, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter to the Editor: Methodological concerns and clinical applicability of ultrasound and bioimpedance for sarcopenia assessment in cirrhosis.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
Same author

Hydrogels loaded with different substances for treating heart failure: a promising therapy.

Frontiers in cardiovascular medicine·2026
Same author

Tanshinone IIA inhibits foam cell formation and alleviates atherosclerosis by regulating the Hedgehog signaling pathway through TRPM2 suppression.

Scientific reports·2026
Same author

Mechanism Investigation and Standardized Equipment Development of Sequential Multi-Frequency Ultrasonic Extraction for Plasticizers in Polymer Materials.

Polymers·2026
Same author

Time-course based assessment of patient factors and their relationship to chemotherapy induced peripheral neuropathy.

Frontiers in pain research (Lausanne, Switzerland)·2026
Same author

Achieved lipid levels and long-term myocardial perfusion assessed by serial CZT-SPECT in post-PCI anterior myocardial infarction.

European journal of nuclear medicine and molecular imaging·2026
Same journal

Biomechanical Performance of Zirconia-Calcium Silicate-Silver Hybrid Dental Crown Under Static and Transient Dynamic Loading: A Finite Element and TOPSIS-Based Multi-Criteria Evaluation.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Synthesis, Characterization, and Implantation of Ferulic Acid-Loaded Chitosan/Aloe vera Hydrogels in Rat Full-Thickness Wound Model.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Double-Crosslinked SIS-Derived Collagen/Alginate Hydrogel With Antibacterial and Pro-Regenerative Activities for Soft Tissue Repair.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Silver and Gold Nanoparticles Promote Antimicrobial Activity and Modulate Inflammation in Escherichia coli-Infected Wounds.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Injectable Thermosensitive Placental ECM-Copper Hydrogel With Endothelial Progenitor Cells for Pressure Ulcer Repair.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same journal

Strut Thickness and Species-Specific Healing Are Key Considerations in Developing Zinc-Based Biodegradable Arterial Stents.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
See all related articles

Researchers created an anisotropic bone graft composite mimicking natural bone structure. This composite, using aligned hydroxyapatite nanoneedles and poly(L-lactic acid) fibers, shows promise for bone repair applications.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Orthopedic Engineering

Background:

  • Natural bone exhibits a hierarchical structure with aligned hydroxyapatite (HA) nanocrystals along collagen fibers.
  • Mimicking this anisotropic architecture is crucial for developing bone graft materials with mechanical properties comparable to natural bone.

Purpose of the Study:

  • To develop an anisotropic bone graft composite that replicates the hierarchical structure and mechanical properties of natural bone.
  • To investigate the influence of aligned hydroxyapatite (HA) nanoneedles and poly(L-lactic acid) (PLLA) fibers on the composite's mechanical performance.

Main Methods:

  • Synthesized HA nanoneedles and melt-drawn PLLA fibers were used as reinforcing components.
  • A modified pultrusion process was employed to induce preferred orientation of the HA and PLLA components.

More Related Videos

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
05:41

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
14:49

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

Related Experiment Videos

Last Updated: May 20, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
05:41

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
14:49

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

  • Wide-angle X-ray diffraction (WAXD) was utilized to analyze the orientation distribution of HA nanocrystals.

    • Main Results:

    • The modified pultrusion process successfully induced preferred orientation of HA nanoneedles and PLLA fibers within the composite.
    • Micromechanical Halpin-Tsai model predictions, incorporating HA amount, shape, and orientation, favorably matched experimental observations.
    • The anisotropic composite demonstrated potential for achieving bone-like modulus and strength.

    Conclusions:

    • An anisotropic bone graft composite with aligned HA nanoneedles and PLLA fibers was successfully fabricated.
    • The study validates the effectiveness of the modified pultrusion process for orienting reinforcing components.
    • The findings support the use of the Halpin-Tsai model for predicting the mechanical behavior of such composites, paving the way for advanced bone regenerative materials.