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Updated: May 20, 2026

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
Published on: December 23, 2016
Polymer micelles for delayed release of therapeutics from drug-releasing surfaces with nanotubular structures
Moom Sinn Aw1, Jonas Addai-Mensah, Dusan Losic
1Ian Wark Research Institute, University of South Australia, Mawson Lakes Boulevard, Adelaide, SA 5095, Australia.
Abstract:
A new approach to engineer a local drug delivery system with delayed release using nanostructured surface with nanotube arrays is presented. TNT arrays electrochemically generated on a titanium surface are used as a model substrate. Polymer micelles as drug carriers encapsulated with drug are loaded at the bottom of the TNT structure and their delayed release is obtained by loading blank micelles (without drug) on the top. The delayed and time-controlled drug release is successfully demonstrated by controlling the ratio of blank and drug loaded-micelles. The concept is verified using four different polymer micelles (regular and inverted) loaded with water-insoluble (indomethacin) and water-soluble drugs (gentamicin).
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