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Updated: May 20, 2026

Screening Ion Channels in Cancer Cells
Published on: June 16, 2023
Calcium channels and pumps in cancer: changes and consequences
Gregory R Monteith1, Felicity M Davis, Sarah J Roberts-Thomson
1School of Pharmacy, The University of Queensland, Brisbane 4075, Australia. gregm@uq.edu.au
Abstract:
Increases in intracellular free Ca(2+) play a major role in many cellular processes. The deregulation of Ca(2+) signaling is a feature of a variety of diseases, and modulators of Ca(2+) signaling are used to treat conditions as diverse as hypertension to pain. The Ca(2+) signal also plays a role in processes important in cancer, such as proliferation and migration. Many studies in cancer have identified alterations in the expression of proteins involved in the movement of Ca(2+) across the plasma membrane and subcellular organelles. In some cases, these Ca(2+) channels or pumps are potential therapeutic targets for specific cancer subtypes or correlate with prognosis.
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