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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

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Endogenous endophthalmitis due to Listeria monocytogenes

J Melamed1, S Kwitko, S Barcaro

  • 1Department of Ophthalmology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Ocular Immunology and Inflammation
|July 25, 2012
PubMed

Insights

This case study highlights Listeria monocytogenes endophthalmitis in an immunosuppressed patient. Early suspicion and treatment are crucial for managing this severe eye infection, even with complications.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Endogenous endophthalmitis is a severe intraocular infection.
  • Listeria monocytogenes can cause endophthalmitis, particularly in immunocompromised individuals.
  • Systemic corticosteroid use and cardiac surgery are risk factors.

Purpose of the Study:

  • To report a case of Listeria monocytogenes endophthalmitis.
  • To discuss the clinical presentation, diagnosis, and management of this rare condition.
  • To emphasize the importance of suspecting Listeria in specific patient populations.

Main Methods:

  • Case report of a patient with Listeria monocytogenes endophthalmitis.
  • Microbiological analysis of aqueous humor and blood cultures.
  • Ophthalmic surgical interventions and medical management.

Main Results:

  • Listeria monocytogenes identified in aqueous humor and blood.
  • Successful treatment with intravenous penicillin.
  • Development of bullous keratopathy and secondary glaucoma.
  • Visual acuity recovery after penetrating keratoplasty and glaucoma surgery.

Conclusions:

  • Listeria monocytogenes endophthalmitis requires high clinical suspicion in immunosuppressed patients with severe anterior uveitis.
  • Key signs include brown hypopyon, elevated intraocular pressure, and corneal edema.
  • Prompt diagnosis and multidisciplinary management are essential for visual recovery.

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