Related Experiment Video
Updated: May 20, 2026

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection
Published on: April 12, 2024
Gelastic seizures due to hypothalamic hamartoma: rapid resolution after endoscopic tumor disconnection
Gemma Incorpora1, Piero Pavone, Danilo Castellano-Chiodo
1a Unit of Pediatrics , Hospital "Garibaldi," , Catania , Italy.
Abstract:
Gelastic epilepsy are focal seizures manifesting as recurrent brief seizures starting as laughter or grimaces. They are most commonly associated with other types of seizures and can be secondary to infectious, malformative, metabolic, or neoplastic processes involving the central nervous system. We report on an 18-month-old girl who presented since the age of 2 months with multiple, recurrent, unprovoked episodes of stereotypical laughter. Brain magnetic resonance study revealed an hypothalamic hamartoma. Endoscopic tumor disconnection of the hamartoma resulted in rapid resolution of neurological symptomatology.
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