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Updated: May 20, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Obese children suffer more often from migraine
Alberto Verrotti1, Alessia Di Fonzo, Sergio Agostinelli
1Department of Pediatrics, University of Chieti, Italy.
Insights
A link exists between migraine and body mass index (BMI). Interventions targeting BMI may help reduce headache frequency and severity in obese individuals with migraine.
Area of Science:
- Neurology
- Metabolic Science
- Gastroenterology
Background:
- Migraine is a complex neurological disorder with numerous comorbidities.
- Obesity is increasingly recognized as a significant factor associated with migraine frequency and disability in both pediatric and adult populations.
Purpose of the Study:
- To investigate the potential relationship between migraine and body mass index (BMI).
- To review existing literature clarifying the association between migraine and BMI.
Main Methods:
- Literature review of translational and basic science research.
- Analysis of studies examining correlations between obesity, migraine frequency, and disability.
Main Results:
- Shared pathophysiological pathways exist between migraine and feeding regulation, involving neurotransmitters (e.g., serotonin), peptides (e.g., orexin), and adipocytokines (e.g., adiponectin, leptin).
- A significant relationship between migraine and BMI is established.
- Weight loss interventions may serve as a therapeutic model for reducing headache burden in obese migraineurs.
Conclusions:
- The interplay between obesity, weight change, and headache outcomes holds significant clinical implications.
- Modifying BMI could be a viable strategy for managing migraine in affected individuals.
Aim:
To determine a possible relationship between migraine and body mass index.
Methods:
Migraine shows a wide spectrum of comorbidities, including cardiocerebral, vascular, psychiatric, metabolic, neurological as well as other pathologies. Recent researches suggest that obesity was significantly correlated with migraine frequency and disability in children, as well as in adult population studies. We reviewed data from the literature to clarify this possible relationship.
Results:
Translational and basic science research shows multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding. Specifically, neurotransmittors such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin have been suggested to have roles in both feeding and migraine. A relationship between migraine and body mass index exists, and therefore, interventions to modify body mass index may provide a useful treatment model for investigating whether modest weight loss reduces headache frequency and severity in obese migraineurs.
Conclusion:
The effect of obesity and weight change on headache outcomes may have important implications for clinical care.
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