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Updated: May 20, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
The underestimated impact of cachexia
Jochen Springer1, Stefan D Anker
1Applied Cachexia Research, Charité Medical School, Berlin, Germany.
Abstract:
This editorial contains views on the importance of animal research in the field of cachexia, a crippling syndrome associated with almost all chronic diseases that dramatically impact on quality of life and survival of the patient. Unfortunately, it is infrequently identified or diagnosed and too rarely treated. Even if treated, the treatment options are extremely limited, as no truly successful therapies have been established so far. Therefore, research in animal models is of outmost importance, but care should be taken in designing these pre-clinical studies. We propose a design as close to clinical trials as possibly and to use primary endpoints that are of clinical relevance.
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