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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...

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Related Experiment Video

Updated: May 20, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

Myeloid malignancies: mutations, models and management.

Anne Murati1, Mandy Brecqueville, Raynier Devillier

  • 1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire; UMR1068 Inserm, Institut Paoli-Calmettes, 27 Bd, Leï Roure, BP 30059, Marseille, 13273, France.

BMC Cancer
|July 25, 2012
PubMed
Summary

Myeloid malignant diseases involve genetic mutations affecting key cellular functions. Targeting epigenetic regulators offers a promising therapeutic strategy for these clonal stem cell disorders.

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Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Myeloid malignant diseases encompass chronic and acute stages, including myelodysplastic syndromes and acute myeloid leukemia.
  • These are clonal disorders originating from hematopoietic stem or progenitor cells.
  • Mutations in signaling pathways, transcription factors, epigenetic regulators, tumor suppressors, and spliceosome components drive these diseases.

Purpose of the Study:

  • To highlight the genetic basis of myeloid malignancies.
  • To emphasize the role of epigenetic deregulation in these diseases.
  • To underscore the therapeutic potential of targeting epigenetic regulators.

Main Methods:

  • Review of genetic mutations in myeloid malignancies.
  • Analysis of protein classes affected by these mutations.
  • Discussion of large-scale sequencing efforts.

Main Results:

  • Mutations in myeloid diseases affect five principal protein classes: signaling pathways, transcription factors, epigenetic regulators, tumor suppressors, and spliceosome components.
  • Comprehensive mutation repertoires will improve classification and identify new therapeutic targets.
  • Epigenetic deregulation is a key feature of myeloid diseases.

Conclusions:

  • Understanding mutation profiles is crucial for myeloid malignancy classification and treatment.
  • Targeting epigenetic regulators represents a highly promising therapeutic avenue for myeloid diseases.