Related Experiment Video
Updated: May 20, 2026

A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
Suppurative granulomatous inflammation in the ileo-anal pouch
Kenji So1, Neil A Shepherd, Trupti Mandalia
1Department of Gastroenterology, Royal Devon and Exeter Hospital, Devon, United Kingdom. kenji.so@nhs.net
Abstract:
Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is commonly performed for medically refractory ulcerative colitis (UC), however with multiple possible complications, most notably pouchitis, cuffitis, Crohn's disease of the pouch and irritable pouch syndrome. We present a unique case of suppurative granulomatous inflammation in the ileal pouch mucosa, most likely infective in nature, that is unrelated to recognised causes of such pathology, especially yersiniosis.
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