Related Experiment Video
Updated: May 20, 2026
02:55
Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue
Published on: October 6, 2023
Translating metabolomics to cardiovascular biomarkers
Todd Senn1, Stanley L Hazen, W H Wilson Tang
1Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
Progress in Cardiovascular Diseases
|July 25, 2012
Summary
Metabolomics analyzes metabolite profiles for physiological insights into cellular processes. This approach offers unique understanding of cardiovascular disease and responses to treatments, advancing biomarker discovery.
Area of Science:
- Biochemistry
- Physiology
- Biomarker Discovery
Background:
- Metabolomics systematically studies metabolite profiles, offering direct physiological insights beyond gene expression and proteomics.
- Metabolic profiling in biospecimens provides a comprehensive view of cellular activity.
- Traditional biomarker discovery pathways are being enhanced by metabolomic advancements.
Purpose of the Study:
- To explore the application of metabolomics in understanding cardiovascular conditions.
- To highlight the role of metabolomics in identifying novel cardiovascular biomarkers.
- To discuss the potential of systemic metabolomics in disease state elucidation and therapeutic response assessment.
Main Methods:
- Utilizing advanced metabolomic tools like nuclear magnetic resonance spectroscopy and mass spectrometry.
- Employing sophisticated bioinformatics and analytical techniques for metabolite measurement.
- Analyzing low-molecular-weight metabolites in various biospecimens.
Main Results:
- Metabolomic profiling provides unique insights into established and novel metabolic pathways.
- Technological advancements enable precise measurement of metabolites.
- Systemic metabolomics offers a deeper physiological understanding of cardiovascular diseases.
Conclusions:
- Metabolomics provides a powerful lens for cardiovascular biomarker discovery and validation.
- Advancements in technology and analysis are expanding the utility of metabolomics.
- Systemic metabolomics holds promise for understanding individual and population responses to interventions and exposures in cardiovascular health.
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...