Related Experiment Video
Updated: May 20, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Modulation of paraoxonases during infectious diseases and its potential impact on atherosclerosis
Ayman Samir Farid1, Yoichiro Horii
1Laboratory of Parasitic Diseases, Faculty of Agriculture, University of Miyazaki, Gakuen-Kibanadai, Nishi 1-1, Miyazaki 889-2192, Japan.
Abstract:
The paraoxonase (PON) gene family includes three members, PON1, PON2 and PON3, aligned in tandem on chromosome 7 in humans and on chromosome 6 in mice. All PON proteins share considerable structural homology and have the capacity to protect cells from oxidative stress; therefore, they have been implicated in the pathogenesis of several inflammatory diseases, particularly atherosclerosis. The major goal of this review is to highlight the modulation of each of the PONs by infective (bacterial, viral and parasitic) agents, which may shed a light on the interaction between infectious diseases and PONs activities in order to effectively reduce the risk of developing atherosclerosis.
Related Concept Videos
Peroxisomes
Gene Regulation in Microbial Communities: Quorum Sensing
Coronary Artery Disease II: Pathophysiology
Atherosclerosis I: Introduction
Atherosclerosis III: Management
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
