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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

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Stem cell regulation by the Hippo pathway.

Samantha E Hiemer¹, Xaralabos Varelas

¹Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.

Biochimica Et Biophysica Acta

|July 25, 2012

Summary

This summary is machine-generated.

The Hippo pathway, regulating TAZ (transcriptional coactivator with PDZ-binding motif) and YAP (Yes1-associated protein), is crucial for stem cell renewal and tissue regeneration. Its dysregulation is linked to cancer stem cell properties and tumor growth.

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Area of Science:

Biochemistry
Developmental Biology
Stem Cell Biology

Background:

The Hippo pathway is a key regulator of organ development and regeneration.
It controls cell proliferation, apoptosis, and differentiation.
TAZ (WWTR1) and YAP are central transcriptional regulators, influenced by mechanosensory and cell polarity cues.

Purpose of the Study:

To review recent studies on the Hippo pathway's role in embryonic and somatic stem cell renewal and differentiation.
To highlight the importance of TAZ and YAP regulation in stem cell biology.

Main Methods:

Literature review of studies on the Hippo pathway in stem cell renewal and differentiation.

Main Results:

Accurate control of TAZ and YAP is vital for stem cell self-renewal and cell fate decisions.
YAP is a key regulator of progenitor cell proliferation and tissue regeneration in vivo.
Aberrant nuclear TAZ and YAP activity promotes tissue overgrowth and cancer stem cell-like properties.

Conclusions:

Understanding Hippo pathway effectors offers insights into pathologies arising from stem cell deregulation.
Discerning Hippo pathway regulatory cues is essential for advancing regenerative medicine.
This review is part of a Special Issue on the Biochemistry of Stem Cells.