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Updated: May 20, 2026

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Published on: November 17, 2018
Regulation of cholesterol biosynthesis and cancer signaling
Andrey Gorin1, Linara Gabitova, Igor Astsaturov
1Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Abstract:
Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.
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