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Related Concept Videos

Nucleotide Excision Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...

Nucleotide Excision Repair

Nucleotide Excision Repair

Base Excision Repair

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...

Base Excision Repair

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

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Related Experiment Video

Updated: May 20, 2026

Visualizing Single-Stranded DNA Foci in the G1 Phase of the Cell Cycle

Visualizing Single-Stranded DNA Foci in the G1 Phase of the Cell Cycle

Published on: December 22, 2023

Nucleotide excision repair: new tricks with old bricks.

Irene Kamileri¹, Ismene Karakasilioti, George A Garinis

¹Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Nikolaou Plastira 100, 70013, Heraklion, Crete, Greece.

Trends in Genetics : TIG

|July 25, 2012

Summary

Nucleotide excision repair (NER) proteins have functions beyond DNA repair, impacting development and disease. Understanding these diverse roles is crucial for explaining clinical variations in NER deficiency disorders.

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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

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Published on: August 21, 2021

Area of Science:

Molecular Biology
Genetics
Developmental Biology

Background:

Nucleotide excision repair (NER) is vital for maintaining genome integrity.
NER defects are linked to cancer, aging, and developmental abnormalities.
The clinical variability of NER defects is not fully explained by DNA repair deficiencies alone.

Purpose of the Study:

To explore the non-DNA repair functions of NER proteins.
To understand how these additional roles contribute to development and disease.

Main Methods:

Analysis of recent scientific literature.
Identification of NER proteins involved in other cellular processes.

Main Results:

NER proteins participate in nucleosome remodeling and histone ubiquitination.
These proteins are involved in transcriptional activation for nuclear receptor signaling, stem cell reprogramming, and mammalian growth.
NER factors have roles extending beyond DNA repair.

Conclusions:

NER proteins possess multifaceted functions beyond DNA repair.
These diverse roles offer new insights into the developmental relevance and clinical heterogeneity of NER defects.
Further research into these non-canonical functions is essential for understanding disease mechanisms.