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Updated: May 20, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
[Neovascular membrane and pregnancy. Treatment with bevacizumab]
I Gómez Ledesma1, M Á de Santiago Rodríguez, I Follana Neira
1Servicio de Oftalmología, Hospital Universitario Virgen de la Vega, Salamanca, España. igomezledesma@yahoo.com
Clinical Case:
Female in her sixth month of pregnancy, with a history of refractive surgery, who consulted due to a metamorphopsia and decrease in visual acuity in the right eye. A presumed ocular histoplasmosis syndrome (POHS) and a subfoveal choroidal neovascular membrane were observed in the fundoscopy. Two monthly doses of intravitreal bevacizumab were given after the labour, but the third dose was never inyected as the patient became pregnant again. She subsequently had a spontaneous miscarriage.
Discussion:
Treatment with intravitreal bevacizumab during pregnancy is controversial as it may increase the risk of miscarriage during the first trimester.
